To elucidate this link, we explore in an experimental autoimmune thyroiditis (EAT) model whether Hmgb1 amplifies immune pathways to exacerbate cognitive and emotional impairments.<h4>Methods</h4>In C57BL/6 mice, EAT was induced by multiple injections of pTg. Here, HMGB1 is linked to autoimmune thyroid disease.