Furthermore, ZNF460 was identified as a transcriptional activator of the NF1 host gene, which in turn upregulated circNF1 expression.<h4>Discussion</h4>Our findings demonstrate that ZNF460-mediated upregulation of circNF1 drives GC metastasis by acting as a molecular scaffold to interact with IGF2BP1 and stabilize HMGA2 mRNA. The gene discussed is HMGA2; the disease is gastric cancer.