CD19 CAR-T cells at a dose of 1 × 10<sup>6</sup> cells per kilogram of body weight were infused after administration of standard lymphodepleting chemotherapy, resulting in a good serological response with reduction of GAD65 serum titers by 95% at day +90, significant clinical improvement in ataxia at day +30 and no evidence of disease progression at day +270 clinically, radiologically and laboratory-wise. Here, GAD2 is linked to Ataxia.