<h4>Objective</h4>This study aimed to evaluate the prognostic significance of the albumin-to-alkaline phosphatase ratio (AAPR) in patients with metastatic colorectal cancer (mCRC) and compare it with the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in the same patient cohort.<h4>Methods</h4>This retrospective study included patients who were followed for mCRC and whose pre-treatment albumin, alkaline phosphatase (ALP), NLR, and PLR values ​​were obtained. The gene discussed is ALB; the disease is metastatic colorectal cancer.