In the hospital cohort, RT-qPCR confirmed dysregulation of the six-gene panel, and serum GRN was markedly elevated in SLE (median [IQR] 43.58 [38.44-54.42] vs. 14.26 [12.79-15.26] ng/mL). The gene discussed is GRN; the disease is systemic lupus erythematosus.