Clinically, high STING expression in PDAC tissues was associated with increased infiltration of cytotoxic T cells and M1-like macrophages, and was identified as an independent predictor of improved patient prognosis.<h4>Conclusions</h4>This study reports AGP regimen as a promising therapeutic modality for PDAC, and provides a detailed mechanism by which a STING-mediated signaling relay from PDAC tumor cells to TAMs boost antitumor immunity and contribute to AGP chemotherapy efficacy. The gene discussed is ATP5MK; the disease is neoplasm.