CACNA1A and Cognitive impairment: The molecular basis of cognitive impairments requires further elucidation in EA2.<h4>Objective</h4>To correlate AI-predicted structural alterations of the CaV2.1 channel with intellectual function observed in patients with EA2.<h4>Methods</h4>Using AlphaFold3, we modeled the wild-type and variant CACNA1A proteins.