The levels of Smad3, phosphorylated Smad3, MMP1 and TIMP1 were assayed by western blotting.<h4>Results</h4>HGD dramatically decreased the serum biochemical indexes, down-regulated the serum biomarkers of liver fibrosis and inflammatory cytokines, reduced the collagen deposition, ameliorated pathological damage. The gene discussed is SMAD3; the disease is Hepatic fibrosis.