<h4>Background</h4>To examine the predictive significance of C-reactive protein (CRP), contrast-enhanced ultrasonography (CEUS), and vascular endothelial growth factor (VEGF) in interventional chemoembolization of primary liver cancer.<h4>Methods</h4>A total of 277 patients with primary liver cancer, 162 males and 115 females, aged 41-73 years, were selected from January 2020 to January 2023 in our hospital. The gene discussed is VEGFA; the disease is liver cancer.