PLOD1 and Insulin resistance: Estrous cycles, ovarian morphology, serum sex hormones, insulin resistance, and oxidative stress in ovarian tissues were assessed.<h4>Results</h4>Combined treatment with metformin and curcumin significantly restored estrous cyclicity, improved ovarian morphology, reduced serum testosterone and luteinizing hormone levels, decreased LH/FSH ratio, and ameliorated insulin resistance compared to monotherapy groups.