The area under the ROC curve (AUC) for PG alone in differentiating GC/EGC from benign gastric diseases ranged from 0.598 to 0.813, whereas the model incorporating PG, Hp-IgG, age, and sex achieved an AUC of 0.851.<h4>Conclusion</h4>Serum PG expression and <i>Hp</i> infection rates differed between patients with GC and those with benign gastric diseases in western Zhejiang. The gene discussed is HP; the disease is infection.