<h4>Objective</h4>The aim of this study is to assess the screening value of serum pepsinogen (PG) expression and <i>Helicobacter pylori</i> (<i>Hp</i>) infection for gastric cancer (GC) in western Zhejiang.<h4>Methods</h4>A retrospective analysis was conducted on patients who underwent gastroscopy at the First People's Hospital of Jiande between July 2020 and July 2023. The gene discussed is HP; the disease is gastric cancer.