This study aims to investigate the effect of lactotransferrin (LTF) upregulation on the pathological changes related to non-small cell lung cancer (NSCLC) <i>via</i> the inhibition of ferroptosis.<h4>Methods</h4>LTF's involvement in NSCLC was investigated through cell experiments and clinical samples. The gene discussed is LTF; the disease is non-small cell lung carcinoma.