The intersection between ChIP-Seq data and RNA sequencing data showed an overall of 12 lncRNAs that were differentially expressed upon FOXO1 knockdown and also have a FOXO1 binding site in their promoter region, namely <i>ZFAS1, LINC00862, SNHG32, LINC01962, SNHG12, 1QCH-AS1, LINC00324, DCXR-DT</i>, <i>GLUD1P2, FAB5P3, JPX, and SMPD4BP</i>.<h4>Discussion</h4>In conclusion, 12 lncRNAs were identified as potential downstream targets of FOXO1, suggesting that those lncRNAs could mediate FOXO1 functions in HCC. The gene discussed is SMPD4BP; the disease is hepatocellular carcinoma.