RPL28 and cancer: Ribosomal proteins (RPs) have been increasingly implicated in cancer progression and drug resistance, but the role and mechanism of ribosomal protein L28 (RPL28) in sorafenib resistance in HCC remains unexplored.<h4>Methods</h4>We investigated the functional role of RPL28 in sorafenib-resistant HCC using HepG2 and HCCLM3 cell models.