GWAS identified CR-associated genetic variants, including a missense mutation in <i>SYNGAP1</i> (Ile1115Thr) not previously linked to cognitive disorders.<h4>Conclusion</h4>Our findings corroborated established risk factors for cardiovascular diseases and identified population-specific patterns, with APOE ε4 showing no significant association. This evidence concerns the gene APOE and Cognitive impairment.