MGMT and neoplasm: We evaluated the patients' clinical conditions at the time of biopsy and upon discharge, the radiological characteristics of the tumor, the histopathological diagnosis, biopsy-related complications, access to oncological treatments along with associated complications and neurological-functional outcomes.<h4>Results</h4>Unmethylated MGMT status, KPS≤70, tumor proximity to the internal capsule and absence of motor hemisyndrome at symptoms onset emerged as possible risk factors.