APOE and atherosclerosis: Immunohistochemistry revealed reduced aortic localization of glucose-related protein 78 compared with the WD group, suggesting that I3C partially alleviated ER stress in atherosclerotic lesions of WD-fed apoE<sup>-/-</sup> mice.<h4>Conclusion</h4>I3C may serve as a feasible compound for preventing atherosclerosis and its associated complications.