Graphpad and SPSS version 27 software were used for statistical analyses.<h4>Results</h4>T2DM patients with vascular complications (DM + VC) displayed significantly lower levels of Nogo-B when compared with T2DM patients without VC (DM) or subjects without diabetes (NC) (p < 0.001). This evidence concerns the gene RTN4 and type 2 diabetes mellitus.