Key findings revealed tumor-type specific chromosomal instability patterns: sarcoma-characteristic chromosome 8 gains, neuroblastoma-enriched 17q amplifications, and TP53 mutations co-occurring with 1q gains-a profile divergent from adult malignancies.<h4>Conclusion</h4>This study establishes the most comprehensive genomic atlas of Chinese pediatric solid tumors to date, delineating subtype-specific oncogenic variants and chromosomal instability signatures. The gene discussed is TP53; the disease is sarcoma.