Compared to previous models, the PE+Pa, BAPN and ANG II combination demonstrates an increase in rupture events, inflammation, and MMP activation.<h4>Conclusions</h4>This murine model, using a synergistic combination of pancreatic elastase and papain, effectively replicates AAA pathophysiology and is ideal for investigating underlying mechanisms and potential therapeutic interventions. Here, AGT is linked to triple-A syndrome.