We hypothesized that combining these agents can synergistically lead to acute AAA rupture models, as well as chronic AAA models that closely resemble human pathology.<h4>Methods</h4>AAAs were induced in 125 male C57BL/6 mice via peri-adventitial exposure for twenty minutes using a cotton ball with either PE, Pa, or a combination of both (PE+Pa), with or without BAPN and ANG II.<h4>Results</h4>Two weeks post-induction, all groups exhibit significantly elevated aortic diameters, increased inflammation, elastin and collagen degradation, and matrix metallopeptidase (MMP) activity. Here, ELN is linked to achalasia-alacrima syndrome.