The anti-inflammatory effects of indole in the liver could potentially also enhance insulin sensitivity, consistent with work showing that indole and related compounds exert hepatoprotective effects in metabolic dysfunction-associated steatotic liver disease (previously known as non-alcoholic fatty liver disease) by reducing the production of proinflammatory mediators [21, 31, 32]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.