GLP1R and Insulin resistance: Given these metabolic benefits of indole, and the preservation of GLP-1’s insulinotropic effect in type 2 diabetes, the same sub-chronic indole treatment protocol was repeated in TALLYHO/JnG mice, a polygenic type 2 diabetes mouse model that exhibits hyperglycaemia and insulin resistance, reflecting the multifactorial nature of human type 2 diabetes [30].