Given these metabolic benefits of indole, and the preservation of GLP-1’s insulinotropic effect in type 2 diabetes, the same sub-chronic indole treatment protocol was repeated in TALLYHO/JnG mice, a polygenic type 2 diabetes mouse model that exhibits hyperglycaemia and insulin resistance, reflecting the multifactorial nature of human type 2 diabetes [30]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.