LMAN1 and viral infectious disease: Overall, our findings uncover LMAN1 as a previously unrecognized host determinant with dual function in CSFV replication and immune evasion, offering new insights into virus-host interactions and revealing a potential antiviral target.IMPORTANCEClassical swine fever virus (CSFV) remains a major threat to global swine health, yet the host factors that the virus exploits to support virus infection and proliferation are not fully understood.