Ferritin, a ligand for CD71, which is overexpressed on AML cells, enables tumor targeting and encapsulates Fe-SH formed by coordination between SH and Fe<sup>3+</sup>. In AML cells, high intracellular glutathione triggers Fe-SH@Fn disassembly: Fe<sup>3+</sup> reduces to Fe<sup>2+</sup> to drive Fenton reaction-mediated ferroptosis, while SH induces ICD. The gene discussed is TFRC; the disease is neoplasm.