MCC-135 has shown potential as an antiseizure medication due to its ability to downregulate NCX and reduce intracellular calcium overload; however, its role and mechanism in epilepsy remain unclear.<h4>Methods</h4>This study employed single-cell analysis and molecular docking to identify the potential molecular targets of MCC-135 in treating epilepsy. Here, TLX2 is linked to epilepsy.