The analyses revealed that molecular targets commonly overexpressed in cancer cells, such as HER2, EGFR, and CEA have been the primary focus in the design of these tracers, together with widely used fluorophores like Cy5 and IRDye800CW combined with radionuclides such as gallium-68, technetium-99m, and copper-64. The gene discussed is ERBB2; the disease is cancer.