In this study, we investigated the effects of SAR405, an inhibitor of vacuolar protein-sorting 34 (VPS34), which is important for regulating the early stage of autophagy, on pleural mesothelioma.<h4>Methods</h4>Human pleural mesothelioma cell lines H28, H2452, and 211H were cultured with SAR405. Here, PIK3C3 is linked to pleural mesothelioma.