Autophagy induction was evaluated in mesothelioma cells transfected with the pMRX-IP-GFP-LC3-RFP-LC3ΔG plasmid, which was developed for the quantitative and statistical estimation of autophagy.<h4>Results</h4>SAR405 treatment alone significantly reduced cell viability, colony formation, and cell invasion, and increased G<sub>2</sub>/M cell cycle arrest. This evidence concerns the gene MAP1LC3A and mesothelioma.