This study integrates systems toxicology with multi-omics to elucidate the role of EIF4EBP1 as a mechanistic bridge connecting PFOS exposure to NSCLC pathogenesis.<h4>Methods</h4>We synthesized chemical-protein interactions from toxicological databases (ChEMBL, STITCH, and SwissTargetPrediction) and disease-associated genes to map the PFOS-NSCLC intersection. The gene discussed is EIF4EBP1; the disease is non-small cell lung carcinoma.