Loss-of-function, gain-of-function, and rescue assays were performed to elucidate the functions of these genes in sepsis.<h4>Results</h4>Septic mice exhibited elevated systemic tumor necrosis factor alpha and interleukin (IL)-6 levels, as well as dysregulated endothelial markers (eNOS downregulation and ET-1 upregulation). Here, TNF is linked to Sepsis.