Conversely, METAP2 overexpression increased IL-8 secretion and apoptosis, which were attenuated by miR-377-3p mimics.<h4>Conclusion</h4>We identified the SNHG5/miR-377-3p/METAP2 axis as a novel regulatory pathway in sepsis-induced endothelial inflammation and apoptosis. The gene discussed is SNHG5; the disease is Sepsis.