PD-1 and PD-L1 expression on CD4+ and CD8+ T cells was analyzed using flow cytometry.<h4>Results</h4>A total of 125 non- Hodgkin Lymphoma patients (65 males and 60 females; median age, 57 years; range, 14-86 years) were included. This evidence concerns the gene CD4 and non-Hodgkin lymphoma.