EGFR and non-small cell lung carcinoma: We compared an early combined therapy (ECT) strategy with a salvage radiotherapy (SRT) strategy.<h4>Methodology</h4>In this multi-center retrospective study, patients with newly diagnosed EGFR-mutant NSCLC and synchronous BM receiving first-line third-generation EGFR-TKIs were classified into ECT (radiotherapy within 90 days of TKI initiation without progression, n=83), SRT (radiotherapy at intracranial progression, n=83), and TKI monotherapy (n=27) groups.