CRP and Hypertension: In the validation cohort, the AUC of XGBoost, KNN, RF, LGBM, SVM, DT, and multivariate logistic regression analysis models were 0.876, 0.822, 0.866, 0.866, 0.871, 0.784, and 0.847, the XGBoost model showed the highest AUC.<h4>Conclusions</h4>This study demonstrates that a family history of hypertension, urine protein, umbilical artery S/D ratio, WBC, TBIL, UA, LDL, TG, CRP, and blood Ca are predictors of HDP progression to SPE.