We evaluated the sensitivity and specificity for pancreatic cancer and analyzed the relationship between the apoA2-i index and pancreatic atrophy or main pancreatic duct dilatation on CT.<h4>Results</h4>A total of 115 patients were included: 38 with pancreatic cancer, 47 with intraductal papillary mucinous neoplasms (IPMNs), and 30 with other conditions. The gene discussed is APOA2; the disease is familial pancreatic carcinoma.