ACAN and osteoarthritis: In a rat osteoarthritis model induced by monosodium iodoacetate, Cel/Lipo+/BHMs effectively mitigated cartilage degeneration by synergistically suppressing the inflammatory response, diminishing the expression of the cartilage degradation enzyme matrix metalloproteinase 13, enhancing the synthesis of type II collagen and aggrecan, and ameliorating subchondral bone microstructure.