<h4>Introduction</h4>The clinical benefit of trastuzumab deruxtecan (T-DXd 5.4mg/kg), the first approved HER2-directed therapy for patients with previously treated HER2-mutant (HER2m) non-small cell lung cancer (NSCLC), was demonstrated in the phase II DESTINY-Lung02 trial. This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.