Dynamic changes also showed strong predictive value, with ΔIL-6 (OR = 1.21) and Δβ2-MG (OR = 1.34) indicating early biological progression before radiologic relapse becomes detectable.<h4>Conclusion</h4>Longitudinal monitoring of IL-6, TNF-<i>α</i>, and β2-MG identifies early inflammatory trajectories linked to lymphoma relapse. Here, IL6 is linked to lymphoma.