These functional impairments were associated with the dysregulation of the androgen receptor (AR)/cyclin-dependent kinase 1 (CDK1)/VEGF signaling pathway.<h4>Discussion</h4>In conclusion, disease-specific iPSCs were successfully generated from phenotype A PCOS patients, providing a robust platform for disease modeling in this distinct subgroup. This evidence concerns the gene VEGFA and polycystic ovary syndrome.