The relationship between Lp-PLA2 and cardiovascular disorders (CVD), diabetic kidney disease (DKD), diabetic retinopathy (DR), diabetic neuropathy (DN), and lower extremity arterial disease (LEAD) was assessed using a qualitative and quantitative analysis.<h4>Results</h4>Twelve studies were included. Here, PLA2G7 is linked to diabetic retinopathy.