The relationship between Lp-PLA2 and cardiovascular disorders (CVD), diabetic kidney disease (DKD), diabetic retinopathy (DR), diabetic neuropathy (DN), and lower extremity arterial disease (LEAD) was assessed using a qualitative and quantitative analysis.<h4>Results</h4>Twelve studies were included. The gene discussed is PLA2G7; the disease is diabetic kidney disease.