Additional brain-region-specific expression quantitative trait locus (eQTL) effects on <i>CRHR1</i> were observed in frontal cortex BA9, hippocampus, and spinal cord, indicating tissue-dependent regulation.<h4>Conclusion</h4>These findings provide evidence for distinct and opposing genetic contributions to SCZ and PTSD. This evidence concerns the gene CRHR1 and post-traumatic stress disorder.