We aimed to systematically characterize its expression patterns, clinical significance, and potential functions across cancers and to validate its biological roles in urologic tumors.<h4>Methods</h4>Leveraging The Cancer Genome Atlas pan-cancer resource, we profiled <i>ALDH1L2</i> across tumor types with respect to expression patterns, clinical outcomes, genomic features, immune contexture, epigenetic associations, and indices of stemness and heterogeneity. Here, ALDH1L2 is linked to cancer.