<i>In vitro</i>, IL-37 neutralization with a specific antibody in septic PBMCs increased the percentages of CD4+ T cells and NKT cells.<h4>Conclusion</h4>This study identifies elevated IL-37 as a potential diagnostic biomarker for pediatric sepsis and demonstrates its role in modulating hyperinflammation and immune cell differentiation. Here, CD4 is linked to Sepsis.