The accuracy of the model was validated using risk and overall survival profiles.<h4>Results</h4>Seven DE-CCGs (CST3, C1QBP, TTF2, EGFR, CDKN2A, PFAS, TRRAP) were identified in TCGA-ESCC, which were correlated with unfavorable ESCC prognosis. This evidence concerns the gene CDKN2A and esophageal squamous cell carcinoma.