Moreover, <i>AQP4</i> and <i>AQP5</i> were significantly downregulated in both lesional and non-lesional hidradenitis suppurativa skin, suggesting a possible involvement in preclinical pathogenic events.<h4>Conclusion</h4>Distinct molecular signatures specific for each lesion type were identified, which may reflect differences in molecular mechanisms. Here, AQP4 is linked to hidradenitis suppurativa.