Gene set variation analysis demonstrated distinct inflammatory pathway signatures in hidradenitis suppurativa lesions, including heightened IL-1 signalling in draining tunnels with significant upregulation of <i>IL1B</i> and its receptor <i>IL1R</i>, but not <i>IL1A.</i> Furthermore<i>, IL17A</i> and <i>IL17F</i> were significantly increased in draining tunnels, inflammatory nodules, and non-draining tunnels, with <i>IL17F</i> showing the highest expression in draining tunnels. The gene discussed is IL1R1; the disease is hidradenitis suppurativa.