This study aimed to investigate the molecular changes potentially associated with bAVM pathogenesis by performing RNA-seq on human microvascular endothelial cells (HMEC-1) overexpressing KRAS, a key driver of BAVM.<h4>Results</h4>HMEC-1 cells overexpressing KRAS were established as an in vitro model of bAVM. Here, KRAS is linked to arteriovenous malformations of the brain.