With single-cell RNA analysis on 13 paired tumor samples from 6 CD30<sup>+</sup> MF patients, we revealed that BV-induced immunogenic cell death (ICD) in both CD30<sup>+</sup> and CD30<sup>-</sup> malignant T cells while specifically enhanced interferon-α (IFNα) and IFNγ responses in CD30<sup>-</sup> subsets. Here, IFNG is linked to neoplasm.