<h4>Background</h4>Second-generation aldosterone-synthase inhibitors (ASIs) may offer a novel treatment for hypertension.<h4>Objectives</h4>The objective of the study was to assess the efficacy and safety of ASIs in this clinical setting.<h4>Methods</h4>We searched major databases for randomized controlled trials (RCTs) assessing ASIs (baxdrostat, lorundrostat, and vicadrostat) in patients with hypertension. The gene discussed is CYP11B2; the disease is Hypertension.