We used a multilayered approach combining clinical data from Malawian pregnant women (<i>n</i> = 711) in the REVAMP trial, a genetic mouse model [<i>Tmprss6</i>-knockout (KO)], and in vitro <i>Plasmodium falciparum</i> cultures to clarify iron-malaria associations. The gene discussed is TMPRSS6; the disease is malaria.