In parallel, peak PCT levels, infection source, and causative pathogen were analyzed retrospectively in uroseptic patients in comparison to other septic sources, and related to Sepsis-related Organ Failure Assessment (SOFA) scores and serum lactate concentrations.<h4>Results</h4>PCT significantly inhibited IL-1β secretion from primary mononuclear leukocytes across the 2.5-75 μg/L concentration range. This evidence concerns the gene IL1B and infection.