IL1B and Sepsis: Among these, those with peak PCT values within 2.5-75 μg/L had significantly lower SOFA scores and lactate levels-established indicators of sepsis severity and prognosis-compared with patients outside this range.<h4>Conclusion</h4>Within a defined concentration range, PCT down-regulates IL-1β secretion and is associated with reduced markers of disease severity in Gram-negative urosepsis, compared to other sepsis entities.