This study aims to elucidate how MKRN2 regulates the RNA-binding protein CSDE1-a molecule linked to autism-related genes-and to explore the functional implications of this interaction in neurodevelopment.<h4>Methods</h4>Using mass-spectrometry screening, we identified CSDE1 as a direct substrate of MKRN2. The gene discussed is MKRN2; the disease is autism.