Nonlinear associations were assessed using generalized additive models with smoothing curves.<h4>Results</h4>After adjusting for age, sex, BMI, Alb, ALP, ALT, BUN, TP, Scr, Lp(a), TC, GGT and hypertension, a higher UHR was significantly associated with lower FR-BMD [β=-0.076, 95%CI(-0.138~-0.015), P = 0.015]. The gene discussed is ALB; the disease is hypertensive disorder.