Lastly, predictive modeling using baseline immune features, including Tph cells, <i>GZMK</i> <sup>+</sup> <i>XCL1</i> <sup>+</sup> CD8<sup>+</sup>, and <i>GZMB</i> <sup>+</sup> <i>CD57</i> <sup>+</sup> CD8<sup>+</sup> T cells, together with clinical features such as anti-CCP3 levels, RF-positivity, and HLA shared epitope status, stratified RA risk and predicted time to onset. The gene discussed is CD8A; the disease is rheumatoid arthritis.